MinLibCas9
Minimal genome-wide human CRISPR-Cas9 library
We developed a data-driven in silico pipeline to design and optimise a minimal genome-wide CRISPR-Cas9...
[Read More]
My research activities fall under the areas of Cancer Systems Biology, Bioinformatics and Machine Learning and focus on the development of computational methods to provide data-driven hypotheses of biological phenomena and precision medicine solutions.
Identifying Drug Mode-of-Action with CRISPR-Cas9
Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens
The Sanger (UK) and Broad (USA) Institutes joined efforts to generate a complete map of...
[Read More]
Sanger Postdoctoral Fellow
My Experience as a Postdoctoral Fellow
Postdoctoral Fellow at Wellcome Sanger Institute
Cancer Cells CRISPR-Cas9 Large-scale Screens
Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens
We presented one of the largest CRISPR-Cas9 screens available to date, and developed a precision...
[Read More]
Crispy: CRISPR-Cas9 Copy Number Bias
Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects
We developed a computational approach to correct copy-number driven deleterious bias induced by Cas9 double-strand...
[Read More]